Abuse-Deterrent Formularies

Abuse-Deterrent Formularies

Medications (most notably opioids) formulated to prevent abuse and misuse of the drug via taking an excess dose or crushing the medication (which releases the drug more quickly) and snorting, smoking or injecting it. ADFs are created by adding a chemical or chemicals (such as naloxen) to the original drug that decrease the user’s response to the substance or produce an adverse reaction when the user alters the original formulation. Another method is to deter the user’s ability to alter the drug’s original formulation, making it impossible to extract the active ingredient by crushing, chewing or mixing with a solvent, such as alcohol. ADFs allow for better management of pain due to the possibility of abuse or misuse being eliminated.