Acetaminophen Combinations

Acetaminophen Combinations

Acetaminophen is the most common drug ingredient in American, found in more than 600 OTC and prescription medications, including generic pain relievers, fever reducers, sleep aids and cough, cold, and allergy formulations. Because of the danger of inadvertent combining acetaminophen-containing products, the FDA has recommended that health care providers discontinue prescribing acetaminophen drug combinations that contain more than 325 mg of acetaminophen per dose. Cases of severe liver injury with acetaminophen have occurred in patients who:

 

  • took more than the prescribed dose of an acetaminophen-containing product in a 24-hour period;
    • took more than one acetaminophen-containing product at the same time; or
    • drank alcohol while taking acetaminophen products.