COX-2 Inhibitor [celecoxib]
COX-2 Inhibitors are a type of non-steroidal anti-inflammatory drug (NSAID) that targets cyclooxygenase-2, an enzyme that causes inflammation and pain. They are used to treat
- Ankylosing spondylitis
- Juvenile rheumatoid arthritis
- Menstrual cramps (primary dysmenorrhea)
- Acute pain (for example, sports injuries)
- Rheumatoid arthritis
COX-2 inhibitors increase the risk of heart attack and stroke, with Vioxx and Bextra being withdrawn from the market in the mid 2000s because of this risk. Celecoxib is the only COX-2 inhibitor now available in the US.