Topical anesthetics are used specifically for numbing the surface of the skin or mucous membrane. See topical analgesics.
Tricyclic and Tetracyclic Antidepressants
These are among the earliest antidepressants developed. Though effective, most have been replaced by antidepressants with few side effects. These block the absorption (reuptake) of the neurotransmitters serotonin and norepinephrine, making more of these chemicals available in the brain and thus boosting mood. Low doses can also relieve chronic pain (especially nerve pain), though the action is not completely understood.
- Desipramine (Norpramin)
- Imipramine (Tofranil)
- Nortriptyline (Pamelor)
- Protriptyline (Vivactil)
- Trimipramine (Surmontil)